Journal article
Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria
- Abstract:
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Case fatality rates in severe falciparum malaria depend on the pattern and degree of vital organ dysfunction. Recent large-scale case-control analyses of pooled severe malaria data reported that glucose-6-phosphate dehydrogenase deficiency (G6PDd) was protective against cerebral malaria but increased the risk of severe malarial anaemia. A novel formulation of the balancing selection hypothesis was proposed as an explanation for these findings, whereby the selective advantage is driven by the ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 542.6KB)
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- Publisher copy:
- 10.7554/elife.43154
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Authors
Funding
+ Australian National Health and Medical Research Council
More from this funder
Grant:
Senior Research Fellowship 1104975
Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 8
- Article number:
- e43154
- Publication date:
- 2019-01-28
- Acceptance date:
- 2019-01-22
- DOI:
- EISSN:
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2050-084X
- Pmid:
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30688212
- Source identifiers:
-
967114
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:967114
- UUID:
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uuid:42948368-92e3-4473-99ff-a1a928d27573
- Local pid:
- pubs:967114
- Deposit date:
- 2019-02-11
Terms of use
- Copyright holder:
- Watson et al
- Copyright date:
- 2019
- Notes:
- This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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