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Journal article

Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria

Abstract:

Case fatality rates in severe falciparum malaria depend on the pattern and degree of vital organ dysfunction. Recent large-scale case-control analyses of pooled severe malaria data reported that glucose-6-phosphate dehydrogenase deficiency (G6PDd) was protective against cerebral malaria but increased the risk of severe malarial anaemia. A novel formulation of the balancing selection hypothesis was proposed as an explanation for these findings, whereby the selective advantage is driven by the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.43154

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0001-5524-0325
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-0482-5689
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-2309-1171
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Grant:
106698/B/14/Z milestone
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
8
Article number:
e43154
Publication date:
2019-01-28
Acceptance date:
2019-01-22
DOI:
EISSN:
2050-084X
Pmid:
30688212
Source identifiers:
967114
Language:
English
Keywords:
Pubs id:
pubs:967114
UUID:
uuid:42948368-92e3-4473-99ff-a1a928d27573
Local pid:
pubs:967114
Deposit date:
2019-02-11

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