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Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Abstract:

Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing-based quantitative analysis of DNA methylation in 98 GC cases and 64 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort and in...

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Journal:
CANCER LETTERS
Volume:
311
Issue:
1
Pages:
85-95
Publication date:
2011-12-01
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
URN:
uuid:42948031-88e3-41f6-8b18-f5381429d03d
Source identifiers:
179584
Local pid:
pubs:179584

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