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Journal article

SSRI enhances sensitivity to background outcomes and modulates response rates: A randomized double blind study of instrumental action and depression.

Abstract:

Serotonin reuptake inhibitors (SSRIs) have immediate effects on synaptic levels of serotonin but their therapeutic effects are often delayed. This delay has been suggested to reflect time required for new learning and therefore that SSRIs might be having effects on the learning process. We examined the effects of elevating serotonin levels, through short-term SSRI administration (escitalopram), on learning about perceptions of instrumental control. A randomised double blind procedure was used...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.nlm.2016.03.004

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
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Funding agency for:
Murphy, R
Grant:
RES-062-23-2525
P1vital CNS Experimental Medicine Consortium More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Neurobiology of learning and memory Journal website
Volume:
131
Pages:
76-82
Publication date:
2016-01-01
Acceptance date:
2016-03-04
DOI:
EISSN:
1095-9564
ISSN:
1074-7427
Source identifiers:
611738
Language:
English
Keywords:
Pubs id:
pubs:611738
UUID:
uuid:4293e7a0-b651-4019-b394-0bf14f3ed215
Local pid:
pubs:611738
Deposit date:
2016-05-16

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