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Are there clinical phenotypes of homozygous sickle cell disease?

Abstract:

The distribution of clinical features was examined in subjects with homozygous sickle cell (SS) disease in the Jamaican Cohort Study to determine whether there is evidence of distinct clustering of symptoms or clinical phenotypes. A twofold model yielded groups that could be interpreted as painful crisis or leg ulcer phenotypes and 78% of patients were classified with 95% confidence into one of these. The painful crisis phenotype also manifested higher frequencies of dactylitis, meningitis/se...

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Authors


Alexander, N More by this author
Serjeant, GR More by this author
Journal:
British journal of haematology
Volume:
126
Issue:
4
Pages:
606-611
Publication date:
2004-08-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:427f2fc4-1020-48b7-9606-1bcff98924ce
Source identifiers:
252796
Local pid:
pubs:252796

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