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An algorithm for statistical alignment of sequences related by a binary tree.

Abstract:

An algorithm is presented that allows the calculation of the probability of a set of sequences related by a binary tree that has evolved according to the Thorne-Kishino-Felsenstein model (1991) for a fixed set of parameters. There are two ideas underlying this algorithm. Firstly, a markov chain is defined that generates ancestral sequences and their alignment at two neighboring nodes in a tree. Secondly, a stochastic walk on the binary tree, that defines a markov chain generating ancestral se...

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Journal:
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Pages:
179-190
Publication date:
2001-01-01
ISSN:
2335-6936
URN:
uuid:427179d1-9279-4017-a32e-0cd78bac3826
Source identifiers:
102837
Local pid:
pubs:102837

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