Journal article icon

Journal article

Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling.

Abstract:

Reactive oxygen species (ROS) play key roles in mucosal defense, yet how they are induced and the consequences for pathogens are unclear. We report that ROS generated by epithelial NADPH oxidases (Nox1/Duox2) during Campylobacter jejuni infection impair bacterial capsule formation and virulence by altering bacterial signal transduction. Upon C. jejuni invasion, ROS released from the intestinal mucosa inhibit the bacterial phosphotyrosine network that is regulated by the outer-membrane tyrosin...

Expand abstract

Actions


Access Document


Publisher copy:
10.1016/j.chom.2012.05.018

Authors


Corcionivoschi, N More by this author
Alvarez, LA More by this author
Strengert, M More by this author
Expand authors...
Journal:
Cell host and microbe
Volume:
12
Issue:
1
Pages:
47-59
Publication date:
2012-07-05
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
URN:
uuid:426c05b9-cc17-4d48-a65a-93a3aeace0ef
Source identifiers:
375596
Local pid:
pubs:375596

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP