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Achieving operational tolerance in transplantation: how can lessons from the clinic inform research directions?

Abstract:

Since the first solid organ transplant between the Herrick twins in 1954, transplantation immunology has sought to move away from harmful immunosuppressive regimens towards tolerogenic strategies that promote long-term graft survival. This has required a concerted multinational effort with scientists and clinicians working towards a common goal. Reports of immunosuppression-free kidney and liver allograft recipients have provided the proof-of-principle, but intentional generation of tolerance...

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Publication status:
Published

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Publisher copy:
10.1111/tri.12081

Authors


Chandrasekharan, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Journal:
Transplant international : official journal of the European Society for Organ Transplantation
Volume:
26
Issue:
6
Pages:
576-589
Publication date:
2013-06-05
DOI:
EISSN:
1432-2277
ISSN:
0934-0874
URN:
uuid:425ec221-a5a1-4312-839d-0cb7a727e98c
Source identifiers:
390882
Local pid:
pubs:390882

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