Journal article icon

Journal article

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

Abstract:

X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a discovery data-set of 1867 females and 1398 males and a replication sample of 3351 females, we show that genetic variation at three autosomal loci is associated with female-specific...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1038/s41467-018-05714-3

Authors


Ward-Caviness, CK More by this author
Carnero-Montoro, E More by this author
Expand authors...
Netherlands Organisation for Scientific Research More from this funder
University of Bristol More from this funder
Expand funders...
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
3738
Publication date:
2018-09-14
Acceptance date:
2018-07-23
DOI:
EISSN:
2041-1723
Pubs id:
pubs:920957
URN:
uri:42467913-1c7b-4e6b-b596-995754b21880
UUID:
uuid:42467913-1c7b-4e6b-b596-995754b21880
Local pid:
pubs:920957
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP