Journal article
Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma.
- Abstract:
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Isocitrate dehydrogenases (IDHs) catalyse oxidative decarboxylation of isocitrate to (Alpha)-ketoglutarate ((Alpha)-KG). IDH1 functions in the cytosol and peroxisomes, whereas IDH2 and IDH3 are both localized in the mitochondria. Heterozygous somatic mutations in IDH1 occur at codon 132 in 70% of grade II-III gliomas and secondary glioblastomas (GBMs), and in 5% of primary GBMs. Mutations in IDH2 at codon 172 are present in grade II-III gliomas at a low frequency. IDH1 and IDH2 mutations caus...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 324.2KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0019868
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Funding
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PloS one More from this journal
- Volume:
- 6
- Issue:
- 5
- Article number:
- e19868
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- UUID:
-
uuid:4232ec34-3dc0-4126-9bc4-df78035fb0ca
- Local pid:
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pubs:141436
- Source identifiers:
-
141436
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- Krell et al
- Copyright date:
- 2011
- Notes:
- Copyright 2011 Krell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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