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Journal article

Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as chemoprophylaxis.

Abstract:

OBJECTIVE: To determine the pharmacokinetic profiles of atovaquone (ATO), proguanil (PROG) and its active metabolite cycloguanil (CYCLO) with respect to possible accumulation and kinetic interaction upon repeated dosing with Malarone. METHODS: Thirteen healthy volunteers first received a single dose and then after 1 week, repetitive daily doses of Malarone (one tablet) for 13 days. For analysis of plasma drug concentrations, blood samples were collected at regular intervals over 8 days after...

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Publication status:
Published

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Publisher copy:
10.1007/s00228-002-0426-9

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Journal:
European journal of clinical pharmacology
Volume:
58
Issue:
1
Pages:
19-27
Publication date:
2002-04-01
DOI:
EISSN:
1432-1041
ISSN:
0031-6970
Source identifiers:
26054
Language:
English
Keywords:
Pubs id:
pubs:26054
UUID:
uuid:4231e8fd-574d-4861-83fc-5c48e0897f7a
Local pid:
pubs:26054
Deposit date:
2012-12-19

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