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Journal article

Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.

Abstract:

The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and impaired lymphatic vascular patterning. However, research into the biological importance of podoplanin has been hampered by the lack of a generally available antibody against the human protein, and its expression in normal tissues and in human malignancies has ...

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Publication status:
Published

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Journal:
American journal of pathology
Volume:
166
Issue:
3
Pages:
913-921
Publication date:
2005-03-01
DOI:
EISSN:
1525-2191
ISSN:
0002-9440

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