Journal article
Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.
- Abstract:
-
The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and impaired lymphatic vascular patterning. However, research into the biological importance of podoplanin has been hampered by the lack of a generally available antibody against the human protein, and its expression in normal tissues and in human malignancies has ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s0002-9440(10)62311-5
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Bibliographic Details
- Journal:
- The American journal of pathology
- Volume:
- 166
- Issue:
- 3
- Pages:
- 913-921
- Publication date:
- 2005-03-05
- DOI:
- EISSN:
-
1525-2191
- ISSN:
-
0002-9440
- URN:
-
uuid:4230356a-b25a-49d3-ae77-a721f3e47801
- Source identifiers:
-
102732
- Local pid:
- pubs:102732
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2005
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