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Magnetic targeting to enhance microbubble delivery in an occluded microarterial bifurcation

Abstract:

Ultrasound and microbubbles have been shown to accelerate the breakdown of blood clots both in vitro and in vivo. Clinical translation of this technology is still limited, however, in part by inefficient microbubble delivery to the thrombus. This study examines the obstacles to delivery posed by fluid dynamic conditions in occluded vasculature and investigates whether magnetic targeting can improve microbubble delivery. A 2D computational fluid dynamic model of a fully occluded Y-shaped micro...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1088/1361-6560/aa858f

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Department:
Oxford, MPLS, Engineering Science
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Author
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Department:
Oxford, MPLS, Engineering Science
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Department:
Oxford, MPLS, Engineering Science
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Author
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Grant:
Digital Economy Programme, Centre for Doctoral Training in Healthcare Innovation (grant EP/G036861/1)
Publisher:
IOP Publishing Publisher's website
Journal:
Physics in Medicine and Biology Journal website
Volume:
62
Issue:
18
Pages:
7451-7470
Publication date:
2017-09-05
DOI:
EISSN:
1361-6560
ISSN:
0031-9155
Pubs id:
pubs:721089
URN:
uri:422f18d3-f734-4a2c-ac9e-394ae40b33d3
UUID:
uuid:422f18d3-f734-4a2c-ac9e-394ae40b33d3
Local pid:
pubs:721089
Paper number:
18

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