Journal article icon

Journal article

MAIT cells contribute to protection against lethal influenza infection in vivo

Abstract:

Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lungs and can contribute to protection against pulmonary bacterial infection. MAIT cells are also activated during human viral infections, yet it remains unknown whether MAIT cells play a significant protective or even detrimental role during viral infections in vivo. Using murine experimental challenge with two strains of influenza A virus, we show that MAIT cells acc...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1038/s41467-018-07207-9

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Van Wilgenburg, B
More from this funder
Funding agency for:
Klenerman, P
More from this funder
Funding agency for:
Hinks, TSC
More from this funder
Grant:
FP7/2007-2013; 608765
Expand funders...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 4706
Publication date:
2018-11-09
Acceptance date:
2018-10-16
DOI:
EISSN:
2041-1723
Pubs id:
pubs:927658
URN:
uri:4218fa55-3efa-474b-abef-ecc18618ac5c
UUID:
uuid:4218fa55-3efa-474b-abef-ecc18618ac5c
Local pid:
pubs:927658

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP