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Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Abstract:

Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory mechanism is impaired in diabetes. Here we show in mice that therapeutic concentrations of insulin inhibit glucagon secretion by an indirect (paracrine) mechanism mediated by stimulation of intra-islet som...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-08193-8

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
OCDEM
Oxford college:
Wolfson College
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0001-6120-3539
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
OCDEM
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0002-3626-4855
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Pages:
Article: 139
Publication date:
2019-01-11
Acceptance date:
2018-12-18
DOI:
EISSN:
2041-1723
Pubs id:
pubs:959896
URN:
uri:42128fc9-5ebd-49a4-8423-9176fbcc6897
UUID:
uuid:42128fc9-5ebd-49a4-8423-9176fbcc6897
Local pid:
pubs:959896
Language:
English
Keywords:

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