- Abstract:
-
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory mechanism is impaired in diabetes. Here we show in mice that therapeutic concentrations of insulin inhibit glucagon secretion by an indirect (paracrine) mechanism mediated by stimulation of intra-islet som...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 984.8KB)
-
- Publisher copy:
- 10.1038/s41467-018-08193-8
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 10
- Pages:
- Article: 139
- Publication date:
- 2019-01-11
- Acceptance date:
- 2018-12-18
- DOI:
- EISSN:
-
2041-1723
- Pubs id:
-
pubs:959896
- URN:
-
uri:42128fc9-5ebd-49a4-8423-9176fbcc6897
- UUID:
-
uuid:42128fc9-5ebd-49a4-8423-9176fbcc6897
- Local pid:
- pubs:959896
- Language:
- English
- Keywords:
- Copyright holder:
- Vergari et al.
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
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