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Journal article

Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59.

Abstract:

The Ly-6 superfamily of cell surface molecules includes CD59, a potent regulator of the complement system that protects host cells from the cytolytic action of the membrane attack complex (MAC). Although its mechanism of action is not well understood, CD59 is thought to prevent assembly of the MAC by binding to the C8 and/or C9 proteins of the nascent complex. Here a systematic, structure-based mutational approach has been used to determine the region(s) of CD59 required for its protective ac...

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Publication status:
Published

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Publisher copy:
10.1084/jem.185.3.507

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Journal of experimental medicine
Volume:
185
Issue:
3
Pages:
507-516
Publication date:
1997-02-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
27589
Language:
English
Keywords:
Pubs id:
pubs:27589
UUID:
uuid:41f6665a-059a-43ea-9866-98a12f3c0f05
Local pid:
pubs:27589
Deposit date:
2012-12-19

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