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A dominant control region from the human beta-globin locus conferring integration site-independent gene expression.

Abstract:

The regulatory elements that determine the expression pattern of a number of eukaryotic genes expressed specifically in certain tissues have been defined and studied in detail. In general, however, the expression conferred by these elements on genes reintroduced into the genomes of cell lines and transgenic animals has turned out to be at a low level relative to that of endogenous genes, and influenced by the chromosomal site of insertion of the exogenous construct. We have previously shown t...

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Publication status:
Published

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Publisher copy:
10.1038/338352a0

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Journal:
Nature
Volume:
338
Issue:
6213
Pages:
352-355
Publication date:
1989-03-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
22466
Language:
English
Keywords:
Pubs id:
pubs:22466
UUID:
uuid:41f4cc34-cc2d-4d7e-8047-3aef427088e1
Local pid:
pubs:22466
Deposit date:
2012-12-19

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