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Journal article

High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity.

Abstract:
Glycosylated analogues of novobiocin, discovered using a broad library of enzymes, have 100-fold improved activity against breast, brain, pancreatic, lung and ovarian cancers and ablated associated off-target activity leading to an up to 2.7 × 10(4) fold increase in selectivity.
Publication status:
Published

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Publisher copy:
10.1039/c1cc13552j

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Journal:
Chemical Communications
Volume:
47
Issue:
38
Pages:
10569-10571
Publication date:
2011-10-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Source identifiers:
186212
Language:
English
Keywords:
Pubs id:
pubs:186212
UUID:
uuid:41ee6b9f-6953-4022-acec-3c5f4c243578
Local pid:
pubs:186212
Deposit date:
2012-12-19

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