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Rejection of tracheal allograft by intrapulmonary lymphoid neogenesis in the absence of secondary lymphoid organs.

Abstract:

BACKGROUND: Obliterative bronchiolitis after lung transplantation is associated with intrapulmonary lymphoid neogenesis. The purpose of this study was to examine the role of lymphoid neogenesis, especially its relationship with secondary lymphoid organs (SLOs) in allograft airway rejection. METHODS: A murine intrapulmonary tracheal transplant model and a conventional subcutaneous tracheal transplant model were tested using wild-type control mice and splenectomized lymphotoxin α knockout (LT)...

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Publisher copy:
10.1097/tp.0b013e318250fbf5

Authors


Wagnetz, D More by this author
Hirayama, S More by this author
Matsuda, Y More by this author
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Journal:
Transplantation
Volume:
93
Issue:
12
Pages:
1212-1220
Publication date:
2012-06-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:41cf2726-15e9-4c90-9783-1c5d431d5c02
Source identifiers:
400588
Local pid:
pubs:400588

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