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NMDA receptor-dependent long-term potentiation in mouse hippocampal interneurons shows a unique dependence on Ca(2+)/calmodulin-dependent kinases.

Abstract:

Long-term potentiation (LTP) of excitatory synaptic transmission plays a major role in memory encoding in the cerebral cortex. It can be elicited at many synapses on principal cells, where it depends on Ca(2+) influx through postsynaptic N-methyl-D-aspartic acid (NMDA) receptors. Ca(2+) influx triggers phosphorylation of several kinases, in particular Ca(2+)/calmodulin-dependent kinase type II (CaMKII). Auto-phosphorylation of CaMKII is a key step in the LTP induction cascade, as revealed by ...

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Publication status:
Published

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Authors


Irvine, EE More by this author
Kullmann, DM More by this author
Journal:
The Journal of physiology
Volume:
584
Issue:
Pt 3
Pages:
885-894
Publication date:
2007-11-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:41c6bb01-2e8b-4e85-b867-7b4cc26552ad
Source identifiers:
222062
Local pid:
pubs:222062

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