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A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.

Abstract:

Glucocorticoid excess increases fat mass, preferentially within omental depots; yet circulating cortisol concentrations are normal in most patients with metabolic syndrome (MS). At a pre-receptor level, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activates cortisol from cortisone locally within adipose tissue, and inhibition of 11beta-HSD1 in liver and adipose tissue has been proposed as a novel therapy to treat MS by reducing hepatic glucose output and adiposity. Using a transfo...

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Publication status:
Published

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Publisher copy:
10.1677/joe-08-0050

Authors


Bujalska, IJ More by this author
Gathercole, LL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Darimont, C More by this author
Ermolieff, J More by this author
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Journal:
The Journal of endocrinology
Volume:
197
Issue:
2
Pages:
297-307
Publication date:
2008-05-05
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
URN:
uuid:41c37ba0-dec4-42fd-91bf-4ed3783d466b
Source identifiers:
482091
Local pid:
pubs:482091

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