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Thesis

Design and utilisation of a poised fragment library against epigenetic proteins

Abstract:

Fragment based drug discovery has become an important method in biomedical research. In particular, it has enabled academic researchers to develop drug-like compounds and chemical probes which can be used for target validation. Recent developments at Diamond Light Source have made X-ray crystallography a viable primary fragment screen. The hits identified by X-ray screening are in general too weak to be verified by orthogonal solution assays, yet such information is a common requ...

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Division:
MSD
Role:
Author

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Supervisor
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Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:41bd8330-188c-4144-afb0-8e1a3ce1b0e7
Deposit date:
2017-07-09

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