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Thesis

Design and utilisation of a poised fragment library against epigenetic proteins

Abstract:

Fragment based drug discovery has become an important method in biomedical research. In particular, it has enabled academic researchers to develop drug-like compounds and chemical probes which can be used for target validation. Recent developments at Diamond Light Source have made X-ray crystallography a viable primary fragment screen. The hits identified by X-ray screening are in general too weak to be verified by orthogonal solution assays, yet such information is a common requ...

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Oakley Benjamin Cox More by this author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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