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Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique

Abstract:

Background: Congenital heart defects are the leading non-infectious cause of death in children. Genetic studies in the mouse have been crucial to uncover new genes and signaling pathways associated with heart development and congenital heart disease. The identification of murine models of congenital cardiac malformations in high-throughput mutagenesis screens and in genetargeted models is hindered by the opacity of the mouse embryo. Results: We developed and optimized a novel method for high-...

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Bamforth, Simon D
Bose, Jens
Bhattacharya, Shoumo
Schneider, Jurgen E
Gruber, Achim D
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Publisher:
BioMed Central
Journal:
BMC Developmental Biology
Issue:
4
Publication date:
2004-01-01
Source identifiers:
http://sers009b.sers.ox.ac.uk/archive/00000850/
Subjects:
UUID:
uuid:41b98eaf-919d-466f-8976-e1714d94e49e
Local pid:
ora:772
Deposit date:
2012-11-15

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