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Big brains, meat, tuberculosis and the nicotinamide switches: co-evolutionary relationships with modern repercussions on longevity and disease?

Abstract:

Meat eating has been an important trigger for human evolution however the responsible component in meat has not been clearly identified. Here we propose that the limiting factors for expanding brains and increasing longevity were the micronutrient nicotinamide (vitamin B3) and the metabolically related essential amino-acid, tryptophan. Meat offers significant sourcing challenges and lack causes a deficiency of nicotinamide and tryptophan and consequently the energy carrier nicotinamide adenin...

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Publisher copy:
10.1016/j.mehy.2014.04.003

Authors


Williams, AC More by this author
Dunbar, RI More by this author
Journal:
Medical hypotheses
Volume:
83
Issue:
1
Pages:
79-87
Publication date:
2014-07-05
DOI:
EISSN:
1532-2777
ISSN:
0306-9877
URN:
uuid:41b6fa87-d679-428b-9ca1-d9d930472f91
Source identifiers:
463012
Local pid:
pubs:463012
Language:
English
Keywords:

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