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The allergen Der p3 from house dust mite stimulates store-operated Ca2+ channels and mast cell migration through PAR4 receptors

Abstract:

The house dust mite is the principal source of perennial aeroallergens in man. How these allergens activate innate and adaptive immunity is unclear, and therefore, there are no therapies targeting mite allergens. Here, we show that house dust mite extract activates store-operated Ca2+ channels, a common signaling module in numerous cell types in the lung. Activation of channel pore-forming Orai1 subunits by mite extract requires gating by STIM1 proteins. Although mite extract stimulates both ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.molcel.2018.03.025

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
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Publisher:
Cell Press Publisher's website
Journal:
Molecular Cell Journal website
Volume:
70
Issue:
2
Pages:
228-241
Publication date:
2018-04-19
Acceptance date:
2018-03-22
DOI:
EISSN:
1097-4164)
ISSN:
1097-2765
Pubs id:
pubs:835037
URN:
uri:41a52a37-0d61-4abc-9b3f-c845b4a8f0d5
UUID:
uuid:41a52a37-0d61-4abc-9b3f-c845b4a8f0d5
Local pid:
pubs:835037

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