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Unifying activity, structure, and spectroscopy of [NiFe] hydrogenases: Combining techniques to clarify mechanistic understanding

Abstract:

Achieving a unified understanding of the mechanism of a multicenter redox enzyme such as [NiFe] hydrogenase is complicated by difficulties in reconciling information obtained by using different techniques and on samples in different physical forms. Measurements of the activity of the enzyme, and of factors which perturb activity, are generally carried out using biochemical assays in solution or with electrode-immobilized enzymes using protein film electrochemistry (PFE). Conversely, spectrosc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.accounts.9b00293

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
ORCID:
0000-0001-5264-464X
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
ORCID:
0000-0001-6444-9382
John Fell Fund More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Accounts of Chemical Research Journal website
Volume:
52
Issue:
11
Pages:
3120-3131
Publication date:
2019-11-01
Acceptance date:
2019-10-14
DOI:
EISSN:
1520-4898
ISSN:
0001-4842
Pmid:
31675209
Language:
English
Keywords:
Pubs id:
1069712
Local pid:
pubs:1069712
Deposit date:
2020-01-31

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