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Journal article

Duration of action of antispasmodic agents: novel use of a mouse model as an in vivo pharmacological assay.

Abstract:

OBJECTIVE: Radial arteries are increasingly used as conduits for coronary artery bypass grafts, but perioperative graft vasospasm remains a concern. In vitro testing has demonstrated the efficacy of phenoxybenzamine and verapamil/nitroglycerin as topical antispasmodic agents, but their duration of action in vivo is unknown. Using an in vivo mouse model, we measured their duration of action in functioning vascular grafts, and compared this to their in vitro duration of action in ungrafted vas...

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Publication status:
Published

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Publisher copy:
10.1016/j.ejcts.2004.06.018

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Journal:
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Volume:
26
Issue:
5
Pages:
988-994
Publication date:
2004-11-01
DOI:
EISSN:
1873-734X
ISSN:
1010-7940
Source identifiers:
104956
Language:
English
Keywords:
Pubs id:
pubs:104956
UUID:
uuid:417ce196-efbb-40c7-9181-c06aad08c219
Local pid:
pubs:104956
Deposit date:
2012-12-19

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