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A comparison of the effects of inhaled furosemide and ethacrynic acid on sodium-metabisulfite-induced bronchoconstriction in subjects with asthma

Abstract:

Inhaled furosemide prevents bronchoconstriction induced by a number of challenges in asthma. One approach to determine the mechanism underlying this protection has been to examine the effects of diuretics with different or overlapping pharmacologic effects. We have compared the effects of furosemide on sodium metabisulfite-induced bronchoconstriction with those of equivalent diuretic doses of ethacrynic acid, a loop diuretic that, unlike furosemide, does not interact directly with the membran...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
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Journal:
American Journal of Respiratory and Critical Care Medicine
Volume:
151
Issue:
2 I
Pages:
337-339
Publication date:
1995-02-05
ISSN:
1073-449X
URN:
uuid:417a296c-1178-43b9-8f4b-c355b74a8529
Source identifiers:
435466
Local pid:
pubs:435466

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