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Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues.

Abstract:

Cajal-Retzius (CR) cells are a transient cell population of the CNS that is critical for brain development. In the neocortex, CR cells secrete reelin to instruct the radial migration of projection neurons. It has remained unexplored, however, whether CR cells provide additional molecular cues important for brain development. Here, we show that CR cells express the immunoglobulin-like adhesion molecule nectin1, whereas neocortical projection neurons express its preferred binding partner, necti...

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Publication status:
Published

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Journal:
Neuron
Volume:
79
Issue:
3
Pages:
461-477
Publication date:
2013-08-01
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Source identifiers:
426684

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