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Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues.

Abstract:

Cajal-Retzius (CR) cells are a transient cell population of the CNS that is critical for brain development. In the neocortex, CR cells secrete reelin to instruct the radial migration of projection neurons. It has remained unexplored, however, whether CR cells provide additional molecular cues important for brain development. Here, we show that CR cells express the immunoglobulin-like adhesion molecule nectin1, whereas neocortical projection neurons express its preferred binding partner, necti...

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Publication status:
Published

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Authors


Gil-Sanz, C More by this author
Franco, SJ More by this author
Martinez-Garay, I More by this author
Espinosa, A More by this author
Harkins-Perry, S More by this author
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Journal:
Neuron
Volume:
79
Issue:
3
Pages:
461-477
Publication date:
2013-08-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:41777931-b4f4-4647-9414-028a4c0e4b56
Source identifiers:
426684
Local pid:
pubs:426684

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