Journal article icon

Journal article

Structured observations reveal slow HIV-1 CTL escape

Abstract:

The existence of viral variants that escape from the selection pressures imposed by cytotoxic T-lymphocytes (CTLs) in HIV-1 infection is well documented, but it is unclear when they arise, with reported measures of the time to escape in individuals ranging from days to years. A study of participants enrolled in the SPARTAC (Short Pulse Anti-Retroviral Therapy at HIV Seroconversion) clinical trial allowed direct observation of the evolution of CTL escape variants in 125 adults with primary HIV...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pgen.1004914

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Expand authors...
More from this funder
Funding agency for:
McLean, A
More from this funder
Funding agency for:
Hurst, J
More from this funder
Funding agency for:
Phillips, R
Expand funders...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
11
Issue:
2
Pages:
e1004914
Publication date:
2015-02-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
506518
Language:
English
Keywords:
Pubs id:
pubs:506518
UUID:
uuid:417684fe-fdb8-40aa-8f4f-89203be154b0
Local pid:
pubs:506518
Deposit date:
2015-03-20

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP