Journal article
Structured observations reveal slow HIV-1 CTL escape
- Abstract:
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The existence of viral variants that escape from the selection pressures imposed by cytotoxic T-lymphocytes (CTLs) in HIV-1 infection is well documented, but it is unclear when they arise, with reported measures of the time to escape in individuals ranging from days to years. A study of participants enrolled in the SPARTAC (Short Pulse Anti-Retroviral Therapy at HIV Seroconversion) clinical trial allowed direct observation of the evolution of CTL escape variants in 125 adults with primary HIV...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(pdf, 1.3MB)
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- Publisher copy:
- 10.1371/journal.pgen.1004914
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Authors
Funding
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 11
- Issue:
- 2
- Pages:
- e1004914
- Publication date:
- 2015-02-01
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
- Source identifiers:
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506518
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:506518
- UUID:
-
uuid:417684fe-fdb8-40aa-8f4f-89203be154b0
- Local pid:
- pubs:506518
- Deposit date:
- 2015-03-20
Terms of use
- Copyright holder:
- Roberts et al
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 Roberts et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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