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Quantitative regulation of inducible genes: comparing models of 'on/off' against continuously variable switches

Abstract:

In order to respond rapidly and appropriately to their environment, cells activate internal signalling pathways, such as the mitogen-activated protein kinase (MAPK) pathways, which elicit appropriate responses through quantitative modulation of gene expression. Conceptually, gene expression may be regulated by a bistable switch or a continuously variable switch. The bistable switch considers the gene in either a stable 'on' state, where transcription happens at a constant rate intrinsic to...

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Caroline Schneider More by this author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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