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cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.

Abstract:

Beta-adrenergic agonists stimulate cardiac contractility and simultaneously blunt this response by coactivating NO synthase (NOS3) to enhance cGMP synthesis and activate protein kinase G (PKG-1). cGMP is also catabolically regulated by phosphodiesterase 5A (PDE5A). PDE5A inhibition by sildenafil (Viagra) increases cGMP and is used widely to treat erectile dysfunction; however, its role in the heart and its interaction with beta-adrenergic and NOS3/cGMP stimulation is largely unknown. In nontr...

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Authors


Takimoto, E More by this author
Champion, HC More by this author
Belardi, D More by this author
Moslehi, J More by this author
Mongillo, M More by this author
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Journal:
Circulation research
Volume:
96
Issue:
1
Pages:
100-109
Publication date:
2005-01-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:416dcbce-8c6f-430e-8b65-235b51747aec
Source identifiers:
237844
Local pid:
pubs:237844

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