Journal article icon

Journal article

Immunization of mice with a recombinant adenovirus vaccine inhibits the early growth of Mycobacterium tuberculosis after infection.

Abstract:

BACKGROUND: In pulmonary Mycobacterium tuberculosis (Mtb) infection, immune responses are delayed compared to other respiratory infections, so that antigen-specific cells are not detected in the lungs earlier than day 14. Even after parenteral immunization with Bacille Calmette Guerin (BCG) or a subunit vaccine, the immune response after Mtb challenge is only slightly accelerated and the kinetics of pulmonary Mtb growth do not differ between naïve and immunized animals up to day 14. METHODS A...

Expand abstract

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0008235

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
PloS one
Volume:
4
Issue:
12
Pages:
e8235
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
URN:
uuid:416a49d5-dcc5-43bd-8b1b-cbe63f58f1f1
Source identifiers:
35016
Local pid:
pubs:35016

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP