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RNA in defense: CRISPRs protect prokaryotes against mobile genetic elements.

Abstract:

The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Three distinct stages in the mechanism can be recognized. Initially, fragments of invader DNA are integrated as new spacers into the repetitive CRISPR locus. Subsequently, the CRISPR is transcribed and the transcript is cleaved by a Cas protein within the repeats, generating short RNAs (crRNAs) that contain the spacer sequence. Finally, crRNAs guide the Cas protein machinery to a complementary inva...

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Publisher copy:
10.1101/cshperspect.a003657

Authors


Brouns, SJ More by this author
van der Oost, J More by this author
Journal:
Cold Spring Harbor perspectives in biology
Volume:
4
Issue:
6
Pages:
a003657-a003657
Publication date:
2012-06-05
DOI:
EISSN:
1943-0264
URN:
uuid:41573887-e83c-4659-968d-d436ee2aacb9
Source identifiers:
382767
Local pid:
pubs:382767

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