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Osteoclast formation and activity in the pathogenesis of osteoporosis in rheumatoid arthritis.

Abstract:

OBJECTIVE: Rheumatoid arthritis (RA) is often complicated by generalized osteopenia due to increased bone resorption by osteoclasts. We analysed a number of cellular and humoral factors that influence osteoclast formation from circulating precursors in RA patients. METHODS: Monocytes isolated from RA patients and normal controls were cultured with macrophage colony-stimulating factor (M-CSF) and nuclear factor-kappaB ligand (RANKL), or with RANKL-expressing UMR106 cells and 1,25 dihydroxyvita...

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Publication status:
Published

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Authors


Hirayama, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Rheumatology (Oxford, England)
Volume:
41
Issue:
11
Pages:
1232-1239
Publication date:
2002-11-05
DOI:
EISSN:
1462-0332
ISSN:
1462-0324
URN:
uuid:4153a01b-47ff-4c14-b5a2-5591e85a150a
Source identifiers:
103836
Local pid:
pubs:103836

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