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Gaseous neuromodulators in the control of neuroendocrine stress axis.

Abstract:

The gaseous neuromodulator carbon monoxide has been shown to reduce the stimulated release of stress neuropeptides, such as vasopressin and oxytocin, from the rat hypothalamus in vitro, while evidence concerning corticotropin-releasing hormone is controversial. In vivo studies have been conducted in the rat, inhibiting heme oxygenase activity--and hence carbon monoxide biosynthesis--in the central nervous system by means of specific heme oxygenase blockers; these studies showed that basal hem...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Volume:
917
Issue:
1
Pages:
638-646
Publication date:
2000-01-01
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
URN:
uuid:414a29ec-3a9b-42c0-870b-014714996e4e
Source identifiers:
138486
Local pid:
pubs:138486
ISBN:
1-57331-287-8

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