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B cell memory to a serogroup C meningococcal conjugate vaccine in childhood and response to booster: little association with serum IgG antibody.

Abstract:

The maintenance of adequate serum Ab levels following immunization has been identified as the most important mechanism for individual long-term protection against rapidly invading encapsulated bacteria. The mechanisms for maintaining adequate serum Ab levels and the relationship between Ag-specific memory B cells and Ab at steady state are poorly understood. We measured the frequency of circulating serogroup C meningococcal (MenC)-specific memory B cells in 250 healthy 6- to 12-y-old children...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1200451

Authors


Perrett, KP More by this author
Clutterbuck, E More by this author
Winter, AP More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
189
Issue:
5
Pages:
2673-2681
Publication date:
2012-09-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:4147f1e2-f747-4a18-a818-92480cbb510a
Source identifiers:
344202
Local pid:
pubs:344202

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