Thesis
Investigating the effects of autophagic perturbations on mitochondrial function in Parkinson’s Disease
- Abstract:
-
Parkinson’s disease is among the fastest growing neurodegenerative disease, projected to impact over 12 million individuals worldwide by 2040. Though extensive research has identified that alpha-synuclein, a canonical Parkinson’s disease gene, impacts proper autophagy and mitophagy, its exact role in the pathogenesis of the disease remains contested. This thesis aims to develop an assay for measuring rates of mitophagy in vivo and to use that assay to understand how alpha-synuclein impacts...
Expand abstract
Actions
Access Document
- Files:
-
-
(Dissemination version, 6.9MB)
-
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Contributors
+ Ryan, B
Role:
Supervisor
ORCID:
0000-0002-6703-3718
+ Wade-Martins, R
Role:
Supervisor
+ Plun-Favreau, H
Role:
Examiner
+ Goding, C
Role:
Examiner
Bibliographic Details
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2020-08-18
Related Items
Terms of use
- Copyright holder:
- Patterson, Ryan Barlow
- Copyright date:
- 2019
If you are the owner of this record, you can report an update to it here: Report update to this record