- Abstract:
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Parkinson’s disease is among the fastest growing neurodegenerative disease, projected to impact over 12 million individuals worldwide by 2040. Though extensive research has identified that alpha-synuclein, a canonical Parkinson’s disease gene, impacts proper autophagy and mitophagy, its exact role in the pathogenesis of the disease remains contested. This thesis aims to develop an assay for measuring rates of mitophagy in vivo and to use that assay to understand how alpha-synuclein impacts...
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Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Role:
- Examiner
- Role:
- Examiner
- Role:
- Supervisor
- ORCID:
- 0000-0002-6703-3718
- Role:
- Supervisor
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Patterson, Ryan Barlow
- Copyright date:
- 2019
Thesis
Investigating the effects of autophagic perturbations on mitochondrial function in Parkinson’s Disease
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Authors
Contributors
+ Plun-Favreau, H
+ Goding, C
+ Ryan, B
+ Wade-Martins, R
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