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Journal article

Inhibitory and stimulatory effects of prostaglandins on osteoclast differentiation.

Abstract:

The effect of prostaglandins (PGs) on osteoclast differentiation, an important point of control for bone resorption, is poorly understood. After an initial differentiation phase that lasts at least 4 days, murine monocytes, cocultured with UMR106 osteoblastic cells (in the presence of 1,25-dihydroxyvitamin D3) give rise to tartrate-resistant acid phosphatase (TRAP) positive osteoclast-like cells that are capable of lacunar bone resorption. PGE2 strongly inhibits TRAP expression and bone resor...

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Publication status:
Published

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Publisher copy:
10.1007/s002239900187

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Calcified tissue international
Volume:
60
Issue:
1
Pages:
63-70
Publication date:
1997-01-01
DOI:
EISSN:
1432-0827
ISSN:
0171-967X
Source identifiers:
103928
Language:
English
Keywords:
Pubs id:
pubs:103928
UUID:
uuid:413fcd03-27db-436d-bfe0-59481de61619
Local pid:
pubs:103928
Deposit date:
2012-12-19

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