Effect of inosiplex on the humoral and cell-mediated immune responses to intradermal human diploid cell rabies vaccine.

Journal article

Antigen-stimulated lymphocyte transformation was studied in recipients of intradermal human diploid cell rabies vaccine (HDCV). HDCV was administered intradermally at 8 different anatomical sites, 0.1 ml each, on day 0; followed by another 4-site injection on day 7. Rabies antigen-stimulated in vitro proliferative response was evident as early as 7 days after starting immunization. It reached a peak on day 14 and had declined by day 28. The cellular proliferative response preceded and roughly...

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Authors: Sriwanthana, B; Phanuphak, P; Thaweepathomwat, M; Warrell, M; Warrell, D

• Journal: Southeast Asian journal of tropical medicine and public health
• Volume: 17
• Issue: 4
• Pages: 543-549
• Publication date: 1986-12-01
• ISSN: 0125-1562
• Language: English
• Keywords: Inosine Pranobex; Rabies virus; Inosine; Rosette Formation; Neutralization Tests; Antibodies, Viral; Female; Male; Rabies Vaccines; Phytohemagglutinins; Lymphocyte Activation; Humans; T-Lymphocytes; Adult; Injections, Intradermal