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Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to Type 2 diabetes

Abstract:

Background: There is considerable interest in the hypothesis that low frequency, intermediate penetrance variants contribute to the proportion of Type 2 Diabetes (T2D) susceptibility not attributable to the common variants uncovered through genome-wide association approaches. Genes previously implicated in monogenic and multifactorial forms of diabetes are obvious candidates in this respect. In this study, we focussed on exons 8-10 of the HNF1A gene since rare, penetrant mutations in these ex...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1371/journal.pone.0006615

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Institution:
Oxford Biomedical Research Centre, Churchill Hospital, Oxford;
Department:
Oxford Centre for Diabetes,Endocrinology & Metabolism
Role:
Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Oxford Centre for Diabetes,Endocrinology & Metabolism
Role:
Author
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Institution:
Oxford Biomedical Research Centre, Churchill Hospital, Oxford;
Department:
Oxford Centre for Diabetes,Endocrinology & Metabolism
Role:
Author
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Institution:
Peninsula Medical School, Exeter, UK
Department:
Institute of Biomedical and Clinical Science
Role:
Author
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Institution:
Peninsula Medical School, Exeter, UK
Department:
Institute of Biomedical and Clinical Science
Role:
Author
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Funding agency for:
Bahram Jafar-Mohammadi
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Funding agency for:
Anna L. Gloyn
National Institute for Health Research Oxford Biomedical Research Centre Programme More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
4
Issue:
8
Pages:
Article: e6615
Publication date:
2009-08-05
DOI:
EISSN:
1932-6203
URN:
uuid:413a6f03-75c1-4eea-83be-8c5ef09f54ff
Local pid:
ora:3094

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