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Breast cancer cells interact with osteoblasts to support osteoclast formation.

Abstract:

Breast cancers commonly cause osteolytic metastases in bone, a process that is dependent upon osteoclast-mediated bone resorption. Recently the osteoclast differentiation factor (ODF), better termed RANKL (receptor activator of NF-kappaB ligand), expressed by osteoblasts has been cloned as well as its cognate signaling receptor, receptor activator of NFkappaB (RANK), and a secreted decoy receptor osteoprotegerin (OPG) that limits RANKL's biological action. We determined that the breast cancer...

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Publisher copy:
10.1210/en.140.10.4451

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Journal:
Endocrinology
Volume:
140
Issue:
10
Pages:
4451-4458
Publication date:
1999-10-01
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
Source identifiers:
429435

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