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Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse.

Abstract:

The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive T cell IS dynamics. Here, we find that IS formation during antigen recognition comprises cycles of stable IS formation and autonomous naive T cell migration. The migration phase is driven by PKCtheta, which is localized to the F-actin-dependent peripheral (p)SMAC. PKCtheta(-/-) T cells formed hypersta...

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Publisher copy:
10.1016/j.cell.2007.03.037

Authors


Xenias, HS More by this author
Dubin-Thaler, B More by this author
Hofman, JM More by this author
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Journal:
Cell
Volume:
129
Issue:
4
Pages:
773-785
Publication date:
2007-05-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:41299093-4781-47fa-87b8-87041e7d9344
Source identifiers:
482597
Local pid:
pubs:482597

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