Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse.

Journal article

The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive T cell IS dynamics. Here, we find that IS formation during antigen recognition comprises cycles of stable IS formation and autonomous naive T cell migration. The migration phase is driven by PKCtheta, which is localized to the F-actin-dependent peripheral (p)SMAC. PKCtheta(-/-) T cells formed hypersta...

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Authors: Sims, T; Soos, T; Xenias, H; Dubin-Thaler, B; Hofman, J

• Journal: Cell
• Volume: 129
• Issue: 4
• Pages: 773-785
• Publication date: 2007-05-01
• DOI: 10.1016/j.cell.2007.03.037
• EISSN: 1097-4172
• ISSN: 0092-8674
• Language: English
• Keywords: Enzyme Inhibitors; Cell Communication; Protein Kinase C; Cell Movement; Mice; Isoenzymes; Animals; Mice, Knockout; Enzyme Activation; Enzyme Repression; Antigen-Presenting Cells; Membrane Lipids; Lymphocyte Activation; T-Lymphocytes; Antigen Presentation; Intercellular Junctions; Wiskott-Aldrich Syndrome Protein