Journal article
Real-time dynamics of mutagenesis reveal the chronology of DNA repair and damage tolerance responses in single cells
- Abstract:
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Evolutionary processes are driven by diverse molecular mechanisms that act in the creation and prevention of mutations. It remains unclear how these mechanisms are regulated because limitations of existing mutation assays have precluded measuring how mutation rates vary over time in single cells. Toward this goal, I detected nascent DNA mismatches as a proxy for mutagenesis and simultaneously followed gene expression dynamics in single Escherichia coli cells using microfluidics. This general ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 267.0KB)
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(Accepted manuscript, zip, 2.7MB)
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- Publisher copy:
- 10.1073/pnas.1801101115
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Authors
Funding
St. John’s College, Oxford
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Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 115
- Issue:
- 28
- Pages:
- E6516-E6525
- Publication date:
- 2018-06-25
- DOI:
- EISSN:
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1091-6490
- ISSN:
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0027-8424
- Pmid:
-
29941584
- Source identifiers:
-
859752
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:859752
- UUID:
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uuid:411e874a-3642-45f5-8f36-39e9f4d51826
- Local pid:
- pubs:859752
- Deposit date:
- 2018-07-02
Terms of use
- Copyright holder:
- National Academy of Sciences
- Copyright date:
- 2018
- Notes:
-
This is the author accepted manuscript following peer review version of the article. The final version is available online from National Academy of Sciences at: 10.1073/pnas.1801101115.
This dataset relating to this journal article is available via ORA at: https://ora.ox.ac.uk/objects/uuid:eb2c482c-dd82-4618-994e-d6c59f0379eb
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