- Abstract:
-
Evolutionary processes are driven by diverse molecular mechanisms that act in the creation and prevention of mutations. It remains unclear how these mechanisms are regulated because limitations of existing mutation assays have precluded measuring how mutation rates vary over time in single cells. Toward this goal, I detected nascent DNA mismatches as a proxy for mutagenesis and simultaneously followed gene expression dynamics in single Escherichia coli cells using microfluidics. This general ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(zip, 2.7MB)
-
(pdf, 267.0KB)
-
- Publisher copy:
- 10.1073/pnas.1801101115
-
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- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 115
- Issue:
- 28
- Pages:
- E6516-E6525
- Publication date:
- 2018-06-25
- DOI:
- EISSN:
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1091-6490
- ISSN:
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0027-8424
- Pubs id:
-
pubs:859752
- URN:
-
uri:411e874a-3642-45f5-8f36-39e9f4d51826
- UUID:
-
uuid:411e874a-3642-45f5-8f36-39e9f4d51826
- Local pid:
- pubs:859752
- Language:
- English
- Keywords:
- Copyright holder:
- National Academy of Sciences
- Copyright date:
- 2018
- Notes:
-
This is the author accepted manuscript following peer review version of the article. The final version is available online from National Academy of Sciences at: 10.1073/pnas.1801101115.
This dataset relating to this journal article is available via ORA at: https://ora.ox.ac.uk/objects/uuid:eb2c482c-dd82-4618-994e-d6c59f0379eb
Journal article
Real-time dynamics of mutagenesis reveal the chronology of DNA repair and damage tolerance responses in single cells
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St. John’s College, Oxford
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