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Elucidation of the monoclonal antibody 5G8-reactive, virulence-associated lipopolysaccharide epitope of Haemophilus influenzae and its role in bacterial resistance to complement-mediated killing.

Abstract:

The phase-variable locus lex2 is required for expression of a Haemophilus influenzae lipopolysaccharide (LPS) epitope of previously unknown structure. This epitope, which is reactive with monoclonal antibody (MAb) 5G8, has been associated with virulence of type b strains. When strain RM118 (from the same source as strain Rd), in which the lex2 locus and MAb 5G8 reactivity are absent, was transformed with lex2 DNA, transformants that were reactive with MAb 5G8 were obtained. Surprisingly, the ...

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Publication status:
Published

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Authors


Griffin, R More by this author
Makepeace, K More by this author
Richards, JC More by this author
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Journal:
Infection and immunity
Volume:
73
Issue:
4
Pages:
2213-2221
Publication date:
2005-04-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:41195551-b284-4f67-8e03-edea8d131ef4
Source identifiers:
115603
Local pid:
pubs:115603

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