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Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex.

Abstract:

In the process of protein synthesis, the small (40S) subunit of the eukaryotic ribosome is recruited to the capped 5' end of the mRNA, from which point it scans along the 5' untranslated region in search of a start codon. However, the 40S subunit alone is not capable of functional association with cellular mRNA species; it has to be prepared for the recruitment and scanning steps by interactions with a group of eukaryotic initiation factors (eIFs). In budding yeast, an important subset of the...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0606880104

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
14
Pages:
5788-5793
Publication date:
2007-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:4108a0e3-2390-42fa-9e0f-7b357b2f61c2
Source identifiers:
23805
Local pid:
pubs:23805

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