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Macrophage-mediated degradation of crosslinked collagen scaffolds.

Abstract:

Biological scaffolds used in tissue engineering are incorporated in vivo by a process of cellular in-growth, followed by host-mediated degradation and replacement of these scaffolds, in which phagocytic cells from the monocyte/macrophage cell lineage play a key role. The chemical degradation of scaffolds with collagenases is well established, but to date this has not been correlated with an in vitro model of cell mediated scaffold degradation. RAW264.7, a murine monocyte/macrophage cell line,...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Materials
Role:
Author
Journal:
Acta biomaterialia
Volume:
7
Issue:
1
Pages:
278-286
Publication date:
2011-01-01
DOI:
EISSN:
1878-7568
ISSN:
1742-7061
Source identifiers:
67458
Language:
English
Keywords:
Pubs id:
pubs:67458
UUID:
uuid:41009b8c-f8b1-4649-af4e-0995242337af
Local pid:
pubs:67458
Deposit date:
2012-12-19

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