Macrophage-mediated degradation of crosslinked collagen scaffolds.

Journal article

Biological scaffolds used in tissue engineering are incorporated in vivo by a process of cellular in-growth, followed by host-mediated degradation and replacement of these scaffolds, in which phagocytic cells from the monocyte/macrophage cell lineage play a key role. The chemical degradation of scaffolds with collagenases is well established, but to date this has not been correlated with an in vitro model of cell mediated scaffold degradation. RAW264.7, a murine monocyte/macrophage cell line,...

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Authors: Yahyouche, A; Zhidao, X; Czernuszka, J; Clover, A

• Publication status: Published
• Journal: Acta biomaterialia
• Volume: 7
• Issue: 1
• Pages: 278-286
• Publication date: 2011-01-01
• DOI: 10.1016/j.actbio.2010.08.005
• EISSN: 1878-7568
• ISSN: 1742-7061
• Language: English
• Keywords: Linear Models; Cell Proliferation; Tissue Scaffolds; Cell Adhesion; Macrophages; Cell Line; Cattle; Biocompatible Materials; Mice; Elastic Modulus; Transition Temperature; Collagenases; Animals; Collagen; Mechanical Phenomena; Cross-Linking Reagents