Vitamin K epoxide reductase (VKOR) recycles reduced vitamin K, which is used subsequently as a co-factor in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. VKORC1, a subunit of the VKOR complex, has recently been shown to possess this activity. Here, we show that VKORC1 is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila, plants, bacteria and archaea. Four cysteine residues and one residue, which is either serine or th...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Vitamin K epoxide reductase: homology, active site and catalytic mechanism.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record