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Vitamin K epoxide reductase: homology, active site and catalytic mechanism.

Abstract:

Vitamin K epoxide reductase (VKOR) recycles reduced vitamin K, which is used subsequently as a co-factor in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. VKORC1, a subunit of the VKOR complex, has recently been shown to possess this activity. Here, we show that VKORC1 is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila, plants, bacteria and archaea. Four cysteine residues and one residue, which is either serine or th...

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Publication status:
Published

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Publisher copy:
10.1016/j.tibs.2004.04.004

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Journal:
Trends in biochemical sciences
Volume:
29
Issue:
6
Pages:
289-292
Publication date:
2004-06-05
DOI:
ISSN:
0968-0004
URN:
uuid:40f894de-eae2-4615-8b6a-08532266fcd2
Source identifiers:
238518
Local pid:
pubs:238518

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