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C/EBPα and GATA-2 mutations induce bilineage acute erythroid leukemia through transformation of a neomorphic neutrophil-erythroid progenitor

Abstract:

Acute erythroid leukemia (AEL) commonly involves both myeloid and erythroid lineage transformation. However, the mutations that cause AEL and the cell(s) that sustain the bilineage leukemia phenotype remain unknown. We here show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations cooperatively induce bilineage AEL, and that the major leukemia-initiating cell (LIC) population has a neutrophil-monocyte progenitor (NMP) phenotype. In pre-leukemic NMPs Cebpa and Gata2 mutations...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-6192-9145
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Publisher:
Cell Press Publisher's website
Journal:
Cancer Cell Journal website
Volume:
37
Issue:
5
Pages:
690-704
Publication date:
2020-04-23
Acceptance date:
2020-03-27
DOI:
ISSN:
1535-6108
Pubs id:
1097888
Local pid:
pubs:1097888

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