Journal article
Synthesis of chemically modified DNA
- Abstract:
-
Naturally occurring DNA is encoded by the four nucleobases adenine, cytosine, guanine and thymine. Yet minor chemical modifications to these bases, such as methylation, can significantly alter DNA function, and more drastic changes, such as replacement with unnatural base pairs, could expand its function. In order to realize the full potential of DNA in therapeutic and synthetic biology applications, our ability to 'write' long modified DNA in a controlled manner must be improved. This review...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Biotechnology and Biological Sciences Research Council
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Grant:
BB/M025624/1
BB/J001694/1
Bibliographic Details
- Publisher:
- Portland Press Publisher's website
- Journal:
- Biochemical Society Transactions Journal website
- Volume:
- 44
- Issue:
- 3
- Pages:
- 709-715
- Publication date:
- 2016-06-09
- Acceptance date:
- 2016-03-24
- DOI:
- EISSN:
-
1470-8752
- ISSN:
-
0300-5127
- Pmid:
-
27284032
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:628374
- UUID:
-
uuid:40ea480a-9c8a-414d-948b-c265a719f64e
- Local pid:
- pubs:628374
- Source identifiers:
-
628374
- Deposit date:
- 2017-02-13
Terms of use
- Copyright holder:
- Shivalingam and Brown
- Copyright date:
- 2016
- Notes:
- © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. This is the accepted manuscript version of the article. The final version is available online from Portland Pres at: 10.1042/BST20160051
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