Continuous generation of ethyl cellulose drug delivery nanocarriers from microbubbles.
PURPOSE: To investigate a new microfluidic method for the continuous preparation of hollow-shell nanoparticles of a hydrophobic polymer and the simultaneous encapsulation within these of a hydrophilic active pharmaceutical ingredient. METHOD: A specially designed and constructed microfluidic device which facilitates at a junction the impingement of two liquids flowing in capillaries kept 60° apart, one containing the polymer ethyl cellulose (EC) and the other active pharmaceutical ingredient...Expand abstract
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